Conclusions
We analyzed the cost-effectiveness of sofosbuvir-based new treatments for genotypes 1, 2 and 3 in the US. Data regarding the natural history of hepatitis C, utility weights, and various costs and transition probabilities were obtained from the literature, and sustained virologic response data associated with new treatments were extracted from clinical studies. Treatment strategies compared in this study were designed based on the data available while complying with drug dosage and administrative recommendations.
We found that for genotype 1 patients, sofosbuvir-based treatments are not cost-effective compared to Viekira Pak and Harvoni. If the price of sofosbuvir were reduced by at least 30 %, then this would change this result. In addition, Sofosbuvir + ribavirin are cost-effective as second-phase treatments following peginterferon + ribavirin initial treatment for genotypes 2 and 3. However, the data for sofosbuvir-involved treatment is limited. Therefore, the results obtained in this study must be interpreted within the model assumptions.