Conclusions
Systematic research showed a growing interest in this treatment approach for the integration of bone-graft, bone-graft substitutes, or bone implants, with an increasing number of published studies over time. However, knowledge on this topic is still preliminary, and the few studies available are mainly of low quality.
We do not have enough evidence to draw clear conclusions on the role of PRP as an augmentation procedure: among RCT and comparative papers, 16 reported favourable results, 18 obtained no significant difference with or without PRP and 6 underlined the doubtful role of PRP.
With regards to materials type, PRP might not be indicated for b-TCP implants, controversial results are obtained with autologous bone, whereas a better potential seems to lie in the augmentation of HA implants.
However, several aspects have to be clarified, such as what biomaterials can benefit the most from PRP and what is the best protocol for PRP both for production and application. Randomized controlled trials are needed to support the potential of this treatment approach and the advantages and disadvantages of PRP as an augmentation procedure to favour implant integration.