Oral Anticoagulation, Aspirin, or No Therapy in Nonvalvular AF

Conclusions

Low-risk patients (i.e., CHA₂DS₂-VASc = 0 [male], = 1 [female]) have a truly low risk for stroke, intracranial bleeding, and major bleeding. With 1 additional stroke risk factor (i.e., CHA₂DS₂-VASc = 1 [male], = 2 [female]), there was a significant increase in event rates, particularly mortality, if nonanticoagulated.